CLINICAL TRIALS AND OBSERVATIONS Clinical and prognostic implications of low or high level of von Willebrand factor in patients with Waldenström macroglobulinemia
نویسندگان
چکیده
1Service d’Hématologie, Hôpital Schaffner, Lens, France; 2Laboratoire d’Hématologie, Centre Hospitalier Universitaire (CHU) de Lille, Lille, France; 3Service d’Anatomo-pathologie, Hôpital Schaffner, Lens, France; 4 CHU Clermont-Ferrand, Hôpital Estaing, Service d’Anatomo-pathologie, Clermont Ferrand, France; 5Laboratoire d’Hématologie, Hôpital Schaffner, Lens, France; 6 Laboratoire de Biochimie, Hôpital Schaffner, Lens, France; 7Departement de Biostatistique, Equipe d’Accueil 2694, Faculte de Medecine, Lille, France; and 8 Service d’Hématologie Clinique Adulte et de Thérapie Cellulaire, Université d’Auvergne, Cancer Resistance Exploring and Targeting (CREaT), Equipe d’Accueil 7283, Institut National de la Sante et de la Recherche Medicale, Centre d’Investigation Clinique-501, CHU Clermont-Ferrand, Hôpital Estaing, Clermont-Ferrand, France
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The diagnosis of type 1 von Willebrand disease (VWD) is based on the presence of bleeding symptoms, reduced von Willebrand factor (VWF) levels, and autosomal inheritance of the phenotype. To better appreciate the contribution of clinical and laboratory data to the final diagnosis of VWD, we computed the likelihoods of having VWD as a function of the bleeding score (LRscore), of VWF level (LRVWF...
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